While we take every precaution possible to ensure only the healthiest of puppies are born and placed for adoption, there are times, even with the best intentions things can happen. When you purchase a puppy from Prims Puppies LLC you will have 3 days to get a check up at your veterinarian to verify our health certification from our vet. Additionally, if you choose to do genetic testing on your puppy you will have 45 days from date of purchase to provide us with the results and if anything shows that we have not previously disclosed, even in person or listed on our website under each breeder, we will gladly refund your money if you choose to return the puppy. If you choose to keep the puppy you will assume all costs with care and no refund will be given. (more detailed information on the health guarantee is available on our puppy contract). If you have any additional questions please send us a message through our contact page link.

The follow is the DNA and Genetic Screenings completed on our Dams and Sires.

Clinical: MDR1 Drug Sensitivity, Alanine Aminotransferast Activity

Blood: P2Y12 Receptor Platelet Disorder, Factor IX Deficiency, Hemophilia B, Factor VII Deficiency, Factor VIII Deficiency, Hemophilia A, Thrombopathia, Von Wilebrand Disease Type III, Type III vWD, Canine Leukocyte Adhesion Deficiency Type I, CLAD I, Canine Leukocyte Adhesion Deficiency Type III, CLAD III, Canine Elliptocytosis, Glanzmann’s Thrombasthenia Type I, May-Hegglin Anomaly, Congenital Macrothrombocytopenia, Prekallikrein Deficiency, Pyruvate Kinase Deficiency, Trapped Neutrophil Syndrome, TNS, Ligneous Membranitis, LM, Platelet Factor X Receptor Deficiency, Scott Syndrome, Methemoglobinemia,Bernard-Soulier Syndrome, BSS

Hormones: Congenital Hypothyroidism, Congenital Dyshormonogenic Hypothyroidism with Goiter, Pituitary Dwarfism, Complement 3 Deficiency, C3 Deficiency, Severe Combined Immunodeficiency, SCID, X-linked Severe Combined Immunodeficiency, X-SCID

Eyes: Progressive Retinal Atrophy, rcd1, Progressive Retinal Atrophy, rcd3, Progressive Retinal Atrophy, CNGA, Progressive Retinal Atrophy, prcd, Progressive Retinal Atrophy, PRA1, Progressive Retinal Atrophy, Progressive Retinal Atrophy, crd1, Progressive Retinal Atrophy, crd4/ cord1, X-Linked Progressive Retinal Atrophy 1, XL- PRA1, Progressive Retinal Atrophy, PRA3, Collie Eye Anomaly, Choroidal Hypoplasia, CEA, Day Blindness, Cone Degeneration, Achromatopsia, Achromatopsia, Autosomal Dominant Progressive Retina Atrophy, Canine Multifocal Rtinopathy, cmr1, Canine Multifocal Retinopathy, cmr2, Canine Multifocal Retinopathy, cmr3, Primary Open Angle Glaucoma, Primary Open Angle Glaucoma and Primary Lens Luxation, Hereditary Cataracts, Early-Onset Cataracts, Juvenile Cataracts, Primary Lens Luxation, Congenital Stationary Night Blindness, Macular Corneal Dystrophy, MCD, Goniodysgenesis and Glaucoma, Pectinate Ligament Dysplasia, PLD, Day Blindness, Cone Degeneration, Achromatopsia, Retina Dysplasia and/or Optic Nerve Hypoplasia, Progressive Retinal Atrophy, Progressive Retinal Atrohy, Bardet-Biedl Syndroe

Kidney and Bladder: 2,8- Dihydroxyadenine Urolithiasis, 2,8-DHA Urolithiasis, Crystinuria Type I-A, Cystinuria Type II-A, Cystinuria Type II-B, Hyperuricosuria and Hyperuricemia or Urolithiasis, HUU, Polycystic Kidney Disease, PKD, Primary Hyperoxaluria, Protein Losing Nephropathy, PLN, X-Linked Hereditary Nephropathy, XLHN, Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy, ARHN, Fanconi Syndrome

Multisystem: Primary Ciliary Dyskinesia, PCD, Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis, Dry Eye Curly Coat Syndrome, CKCSID, X-linked Ectodermal Dysplasia, Anhidrotic Ectoderma Dysplasia, XHED, Renal Cystadenocarcinoma and Nodular Dermatofibrosis, RCND, Canine Fucosidosis, Glycogen Storage Disease Type II, Pompe’s Disease, GSD II, Glycogen Storage Disease Type IA, Von Gierke Disease, GSD IA, Glycogen Storage Disease Type IIIA, GSD IIIA, Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A, MPS IIIA, Mucopolysaccharidosis Type II, Sly Syndrome, MPS VII, Gycogen Storage disease Type VII,Phosphofructokinase Deficiency, PFK Deficiency, Lagotto Storage Disease, Neurona Ceroid Lipofuscinosis 1, NCL 1, Neurona Ceroid Lipofuscinosis 2, NCL 2, Neuronal Ceroid Lipofuscinosis, Cerebellar Ataxia, NCL4A, Neuronal Ceroid Lipofuscinosis 5, NCL 5, Neuronal Ceroid Lipofuscinosis 6, NCL 6, Neuronal Ceroid Lipofuscinosis 7, NCL 7, Neuronal Ceroid Lipofuscinosis 8, NCL 8, Neuronal Ceroid Lipofuscinosis 10, NCL 10, Neuronal Ceroid Lipofuscinosis 5, NCL 5, Late-onset Neuronal Ceroid Lipofuscinosis, NC 12, GM1 Gangliosidosis, GM2 Gangliosidosis, Globoid Cell Leukodystrophy, Krabbe disease, Neuronal Ceroid Lipofuscinosis 8, NCL 8, Mucopolysaccharidosis IIIB, Sanfilippo Syndrome Type B, MPS IIIB

Other Systems: Autosomal Recessive Amelogenesis Imperfecta, Familial Enamel Hypoplasia, Persistent Mullerian Duct Syndrome, PMDS, Neonatal Interstitial Lung Disease, Recurrent Inflammatory Pulmonary Disease, RIPD, Early Onset Adult Deafness EOAD, Early Bilateral Deafness

Brain and Spinal Cord: Alexander Disease, Cerebellar Abiotrophy, Neonatal Cerebellar Cortica Degeneration, NCCD, Cerebellar Ataxia, Progressive Early-Onset Cerebellar Ataxia, Cerebellar Hypoplasia, Spinocerebellar Ataxia, Late-Onset Ataxia, LoSCA, Spinocerebellar Ataxia with Myokymia and/or Seizures, Hereditary Ataxia, Cerebellar Degeneration, Benign Familial Juvenile Epilepsy, Remitting Focal Epilesy, Degenerative Myelopathy, DM, Fetal-Onset Neonatal Neuroaxonal Dystrophy, Hypomyelination and Tremors, Shaking Puppy Syndrome, X-linked Generalized Tremor Syndrome, L-2-Hydroxyglutaricaciduria, L2HGA, Neonatal Encephaloathy with Seizures, NEWS, Narcolepsy, Progressive Neuronal Abiotrophy, Canine Multiple System Degeneration, CMSD, Juvenile Laryngeal Paralysis and Polyneuroathy, Polyneuropathy with Ocular Abnormalities and Neuronal Vacuolation, POANV, Hereditary Sensory Autonomic Nuuropathy, Acral Mutilation Syndrome, AMS, Sensory Neuropathy, Juvenile-Onset Polyneuropathy, Leonberger Polyneuropathy 1, LPN1, Juvenile Myoclonic Epilepsy, Juvenile-Onset Polyneuropathy, Leonberger Polyneuropathy 2, LPN2, Spongy Degeneration with Cerebellar Ataxia 1, SDCA1, SeSAME/ EAST Syndrome, Spongy Degeneration with Cerebellar Ataxia 2, SDCA2, Neuroaxonal Dystrophy, NAD, Leukodystrophy, Spinocerebellar Ataxia

Heart: Dilated Cardiomyopathy, DCM1, Dilated Cardiomyopathy, DCM2 ,Long QT Syndrome, Cardiomyopathy and Juvenile Mortality, Dilated Cardiomyopathy, DCM

Muscular: Muscular Dystrophy, Limb Girdle Muscular Dystrophy, Ullrich-like Congenital Muscular Dystrophy, Centronuclear Myopathy, CNM, Exercise-Induced Collapse, EIC, Myotonia Congenita, Myotubular Myopathy 1, X-linked Myotubular Myopathy, XL-MTM, Inflammatory Myopathy, Nemaline Myopathy, Ullrich-like Congenital Muscular Dystrophy, Limb-Girdle Muscular Dystrophy 2D

Metabolic: Hypocatalasia, Acatalasemia, Pyruvate Dehydrogenase Deficiency, Malignant Hyperthermia, Mucopolysaccharidosis Type VI, Maroteaux-Lamy Syndrome, MPS VI, Succinic Semialdehyde Dehydrogenase Deficiency

Gastrointestinal: Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption, Inherited Selected Cobalamin Malabsorption with Proteinuria, Lundehund Syndrome

Neuromuscular: Congenital Myasthenic Syndrome, CMS, Myasthenia Gravis-Like Syndrome, Episodic Falling Syndrome, Paroxysmal Dyskinesia, PxD, Demyelinating Polyneuropathy, Laryngeal Paralysis

Skin and Connective Tissues: Dystrophic Epidermolysis Bullosa, Ectodermal Dysplasia, Skin Fragility Syndrome, Ichthyosis, Epidermolytic Hyperkeratosis, Ichthyosis, ICH1 , Ichthyosis, Focal Non-Epidermolytic Palmoplantar Keratoderma, Pachyonychia Congenita, Hereditary Footpad Hyperkeratosis, Heriditary Nasal parakeratosis, HNPK, Musladin-Lueke Syndrome, MLS, Oculocutaneous Albinism, OCA, Bald Thigh Syndrome, Lethal Acrodermatitis, LAD, Ehlers Danlos, Junctional Epidermolysis Bullosa, Hereditary Nasal arakeratosis

Skeletal: Cleft Lip and / or Cleft Palate, Hereditary Vitamin D- Resistant Rickets, Oculoskeletal Dysplasia 2, Dwarfism-Retinal Dysplasia 2, drd2, OSD2, Osteogenesis Imperfecta, Brittle Bone Disease, Osteochondrodysplasia, Skeletal Dwarfism, Skeletal Dysplasia 2, SD2, Craniomandibular Osteopathy, CMO, Raine Syndrome, Canine Dental Dental Hypomineralization, Chondrodystrohy and Intervertebral Disc Disease, CDDY/ IVDD, Type I IVDD, Chondrodystrophy

According to the Humane Society Veterinary Medical Association, HSVMA there are specific congenital disorders that can be passed in the Yorkshire Terrier breed; according to their list these include;

Cataracts: as in humans, a change in structure of the lens of the eye leading to cloudiness and usually to blindness

Collapsed trachea: a condition where the cartilage rings that make up the trachea are malformed and tend to collapse easily.

Cryptorchidism: a condition where one testicle does not descend into the scrotal sac.

Cushing’s disease (hyperadrenocorticism): a common disease characterized by an excess secretion of corticosteroids from the adrenal glands. Most often seen in middle aged females.

Demodicosis: a kind of skin disease (mange) caused by microscopic Demodex canis mites living within the skin layers and producing an immunodeficiency syndrome.

Distichiasis: abnormaly growing eyelashes

Entropion: an abnormal rolling in of the eyelid

Hepatic portosystemic shunt or arteriovenous fistula: a malformation of blood vessels in the liver or an abnormal communication between the arteries and veins in that liver.

Hydrocephalus: a condition where there is an abnormal accumulation of fluid in the ventricles of the brain.

Hyperadrenocorticism or Cushing’s disease: a common disease where the adrenal glands are overactive.

Hypogycemia: a syndrome where the animal has an abnormally low blood glucose

Hypoplasia of dens: a condition where part of the second vertebra fails to develop fully and leads to instability.

Hypothyroidism: a very common endocrine disease where the body produces an abnormally low amount of thyroid hormones. An autoimmune destruction of the thyroid gland which affects more that 50 dog breeds.

Keratitis sicca: a condition where one or both eyes do not produce a normal amount or type of tears.

Keratoconjunctivitis sicca: Also called “dry eye” and associated with hypothyroidism in some breeds such as the American cocker spaniel.

Legg-Perthes disease: a disease where the blood vessels feeding the femoral head (top part of the thigh bone) shrink, leading to starvation and death of the femoral head (the ball of the ball-and-socket joint of the hip). Also called Legg-Calve’-Perthes disease. Most common in large breeds.

Lymphocytic thyroiditis: an autoimmune disease causing inflammation and destruction of the thyroid gland, which becomes infiltrated with lymphocytes (white blood cells) and leads to hypothyridism. This is the most common endocrine disease of the dog and has an inherited predisposition.

Patella luxation: a condition where the knee caps slide in and out of place

Patent ductus arteriosus: failure of the vessel remnant joining the aorta and pulmonary artery in fetal life to close properly at birth, thereby shunting blood away from the lungs.

Persistent pupilary membrane: a developmental abnormality where the membrane forming the iris does not form properly.

Portosystemic shunt: a congenital anormaly of blood vessels supplying the liver, causing varying degrees of liver dysfunction or failure. Also can be manifested as microvascular dysplasia. Common in breeds such as the Yorkshire and Cairn terrier, but can also occur in any breed.

Progressive retinal atrophy: a disease where the retina slowly deteriorates, producing night blindness.

Retinal detachment: where the retina is unattached to the back of the eye

Retinal dysplasia: a condition where the retina is malformed

Seborrhea: a skin disease with excess scaling of the skin and often an excess of sebum, (oil-like substance) and odor.

Thyroiditis: an autoimmune inflammatory disease of the thyroid gland.

Von Wilebrand Disease: a type of bleeding disorder caused by defective blood platelet function. Occurs in 59 dog breeds but most often in Doberman pinschers. An autosomal trait affecting both sexes.